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M94A3005.TXT
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1994-10-25
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Document 3005
DOCN M94A3005
TI Multiple coin lesions revealing a primary pulmonary lymphoma in a
patient with AIDS.
DT 9412
AU Allegre T; Cailleres S; Tadrist Z; Leprince Y; Jarry JM; Sault MC; Blanc
AP; Hopital Cezanne, Aix-en-provence, France.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):175 (abstract no. PB0128). Unique
Identifier : AIDSLINE ICA10/94369570
AB Pulmonary lymphoma is rarely reported in AIDS patients. A 28 year old
HIV infected male was admitted to the hospital with dyspnea, cough, and
fever. He was intravenous drug user and his past history was remarkable
for pneumocystis carini pneumonia; The CD4 positive cell count was
16/mm3.X-ray film of the chest showed multiple bilateral pulmonary
nodules; Computed tomographic scan revealed also many lung nodules.
Biopsy specimen was obtained by thoracoscopy and revealed a high grade
polymorphic non Hodgkin's lymphoma of B cell type; the search of viral
protein in the tumor showed existence of latent membrane proteins of
Epstein Barr virus (EBV): LMP1 and EBNA2. Other radiological
investigations, bone marrow biopsy were negative. Patient were treated
with combined chemotherapy including adriamycin, cyclophosphamide,
vincristine, methotrexate, and steroid, without success; he died ten
months later after diagnosis of lymphoma. Lymphoma, the most prevalent
HIV releated neoplasm after Kaposi's sarcoma, occurs in four to ten
percent of patients with HIV disease, and .EBV seems to be associated in
many cases. The most frequent sites after nodals involvement are: the
central nervous system, the gastro intestinal tract, the liver and the
bone marrow. Pulmonary involvement has been reported in less than ten
percent of cases.
DE Adult Antineoplastic Agents, Combined/THERAPEUTIC USE Biopsy Case
Report Coin Lesion, Pulmonary/*DIAGNOSIS/DRUG THERAPY/PATHOLOGY
Diagnosis, Differential Fatal Outcome Herpesvirus 4, Human Human
Lung/PATHOLOGY Lung Neoplasms/*DIAGNOSIS/DRUG THERAPY/PATHOLOGY
Lymphoma, AIDS-Related/*DIAGNOSIS/DRUG THERAPY/PATHOLOGY Male
Pneumonia, Pneumocystis carinii/DIAGNOSIS/DRUG THERAPY/PATHOLOGY Tumor
Virus Infections/DIAGNOSIS/DRUG THERAPY/PATHOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).